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Odontogenic lesions range from developmental anomalies to benign
and malignant neoplasms. Ameloblastoma, known for its locally
invasive behaviour and high risk of recurrence, is a frequently
encountered benign ectodermal odontogenic tumour, while
ameloblastic fibroma is a mixed odontogenic tumour with relatively
lesser frequency. These tumors demonstrate varying inductive
interactions between odontogenic epithelium and odontogenic
ectomesenchyme of which extracellular matrix (ECM) plays an
important role. Tenascin, a large glycoprotein component of ECM is
involved in cell-to-cell and cell-ECM interactions. A diverse
expression of tenascin has been reported in various lesions, where
it may affect cellular proliferation, differentiation and
migration. Till to date, there are only a few reports on the role
played by tenascin in odontogenic tumors. The purpose of this study
was to analyze the expression and distribution of tenascin in
ameloblastoma and ameloblastic fibroma with varied stromal back
ground thus to understand their phenotypical behavior.
A cyst is an epithelium lined pathologic space. Cysts can be
encountered in any part of the body and are relatively more common
in head and neck region. Epithelial-lined jaw cysts, also known as
odontogenic cysts, which are probably the most common destructive
lesions of the jaw bones. These entities can be categorised as
developmental and inflammatory in origin. Recent studies focus on
the importance of epithelial mesenchymal interactions in the growth
of the odontogenic cysts and it has been suggested that stroma is
essential and responsible for maintaining the epithelial tissues.
Both these make up an ecosystem with continuous molecular
interactions, hence any alterations in the stromal compartment can
bring about changes in the adjacent epithelium. The present study
was done to evaluate the nature of the connective tissue walls of
odontogenic cysts, like OKC, dentigerous cyst and radicular cyst
using picrosirius red stained sections and polarizing microscopy.
Further it was intended to asses if the capsular connective tissue
can affect the nature of overlying epithelium, thus emphasizing the
role of epithelial-mesenchymal interactions in biological behaviour
of the cysts.
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